This research was conducted with the aim of identifying the key factors influencing the relations between Iran and the Zionist regime, designing potential future scenarios (2025–2035), assessing their likelihood and consequences, and proposing strategic responses. This descriptive-analytical study adopts a futurology approach using the scenario analysis method. The statistical population consisted of relevant scientific sources, and purposive sampling was employed. Secondary data were collected through a review of Persian and Latin sources (library and documentary). Findings indicate that key factors include ideology, the nuclear program, geopolitics, security, economy, cyber warfare, and the role of major powers. By integrating the moderating variable of “domestic political transformations in Iran, the U.S., and the Zionist regime,” four scenarios were designed: 1) Balance of Power World, 2) Diplomacy and Limited Tension World, 3) Hidden War World, and 4) Direct Confrontation World. Probability assessment reveals that the “Hidden War” scenario is highly probable, acting as a dynamic equilibrium resilient to political shocks. The “Diplomacy and Limited Tension” scenario is likely in the short term but unstable in the long term. The “Balance of Power” scenario has a low to medium probability, while the “Direct Confrontation” scenario has a low probability, though it remains a critical tail risk with catastrophic consequences. The conclusion suggests that the probability of widespread war is low, but indirect tensions will persist. Strategic responses are proposed for Iran